Acute pain brings an alarm to the body of possible injuries and has normally a protective purpose. Conversely, chronic pain does not convey any useful information and has no biological benefit. Chronic pain is a major clinical problem that affects up to 30% of persons in the world. It includes neuropathic pain, caused by dysfunction, damage, or degeneration of the sensory nervous system.

It gives a feeling of general discomfort and lowers the quality of life. Medications, massage therapy, acupuncture, electrical stimulation, nerve blocks, and surgery are some traditional therapies for chronic pain: all unsatisfactory.

Hence, in this article, we will discuss how can Palmitoylethanolamide can help deal with this issue of Chronic pain and Neurogenerative Disease. So, become getting into Palmitoylethanolamide (PEA) at https://www.cofttek.com/product/544-31-0/  let us see what PEA is all about.

Palmitoylethanolamide (PEA) is both a naturally occurring lipid ingredient contained in foods/dietary supplements and an endogenous lipid mediator belonging to the class of fatty acid ethanol amides.

Evidence indicates that PEA is an important anti-inflammatory, analgesic, and neuroprotective mediator acting on several molecular targets in both central and peripheral organs and systems.

THE EFFECT OF PALMITOYLETHANOLAMIDE ON NEUROGENERATIVE DISEASES:

• Neurodegeneration, such as that observed in Alzheimer’s and Parkinson’s diseases (AD and PD) and multiple and amyotrophic lateral sclerosis (MS and ALS), consists of a gradual neuronal cell death affecting a specific cellular population of the CNS causing a progressive disability such as cognitive impairments, behavioral and motor dysfunctions up to paralysis. PEA has demonstrated to play a neuroprotective role in several experimental models of neurodegenerative diseases.

• In an animal model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) the chronic treatment with PEA counteracted behavioral impairments, motor dysfunction, the loss of nigrostriatal neurons, astrocytes activation, altered expression of iNOS and microtubule-associated proteins.

• The treatment with PEA also restored the cognitive behavior and the altered expression of microtubule-associated protein (MAP-2) in a PPARα-dependent way. The co-PEA/ luteolin composite was also effective in reversing the altered expression of iNOS, GFAP, and brain-derived neurotrophic factor (BDNF) expression in hippocampal slice culture exposed to Aβ1-42 peptide.

• Thus, the neuroprotective effect of PEA is based on its capability to revert the altered expression of proteins strictly associated with AD or PD and to down-regulated the activation of pro-inflammatory/pro-apoptotic factors leading to neural loss. Thus, PEA seems to enhance or compensate endogenous defense mechanisms counteracting neuroinflammation and neurodegeneration development.

CONCLUSION AND SUMMARY:

The capability of PEA to modulate protective response in inflammatory, neurodegenerative, and chronic pain conditions suggests that endogenous PEA may be a component of the homeostatic system involved in the resolution program of neuroinflammation.

Consequently, the administration of exogenous PEA like Pterostilbene or the inhibition of PEA degradation may be a therapeutic strategy to counteract the neuroinflammation at the base of several neurological disorders.

Read More

While the title implies, A Course in Miracles is a training device. It teaches us what is real and what is unreal, and leads us to the direct connection with our own Inner Teacher.

The Course is arranged in three parts: a text, a workbook for students and an information for teachers. The Text presents the concepts underlying the Course. The workbook contains 365 daily lessons giving students the opportunity to apply and go through the concepts on a functional level. The teacher’s manual is presented in a concern and answer format, addressing typical questions that a student may ask; it also supplies a clarification of terms used throughout the Course.

On How it All Began

The Course was published by Helen Schucman and Bill Thetford, two highly trained and successful Professors of Psychology at Columbia University’s College of Physicians and Surgeons in New York City. Helen was the scribe for the Course, writing down in shorthand the inner messages she received. Bill typed what Helen wrote. It took an overall total of seven years to complete A Course in Miracles, which was initially published in 1976 in the United States. Helen wrote additional pamphlets. Her Song of Prayer was published in 1977 and The Gift of God in 1978.

Over the past 34 years, the popularity of A Course in Miracles has grown and spread worldwide. It’s been translated into 18 different languages and more translations come in the works. Throughout the world, people gather with other like-minded students to learn the Course together in order to better understand the Course’s message a course in miracles unity online radio. In this era of electronic and social networking, A Course in Miracles could be obtained in e-book format, on CD, and through iPhone Apps. You can connect to other Course students on Facebook, Yahoo Groups, Twitter, and numerous other websites.

Experiencing the Course

The Course was created to be considered a self-study tool. However, many students realize that their first interaction with the material is difficult and overwhelming – the change in perspective so it offers is unlike traditional thinking. Taking an introductory class with a skilled facilitator or teacher provides for a gentler opening to these new ideas and a far more fulfilling experience.

There are numerous classes and courses of study based upon the philosophy of A Course in Miracles, and even specific classes on key Course concepts, such as for instance True Forgiveness or Cause and Effect. Such classes give students the chance to experience the theory and application of specific material more deeply. Through such deep experience, many students discover the reassurance of inner peace and the joy of knowing the Inner Teacher.

“This Course is a beginning, not an end… Forget about specific lessons are assigned, for there’s no more need of them. Henceforth, hear nevertheless the Voice for God… He will direct your efforts, telling you exactly how to proceed, how to direct the mind, and when to come to Him alone, seeking His sure direction and His certain Word (Workbook, p. 487).

Read More